Gene

ak3

ID

ZDB-GENE-040426-2142

Name

adenylate kinase 3

Symbol

ak3 Nomenclature History

Previous Names

ak3l1
id:ibd3034
sb:cb845
wu:fa02c11
wu:fc20h08
zgc:64135

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to enable adenylate kinase activity and nucleoside triphosphate adenylate kinase activity. Acts upstream of or within myeloid cell development. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Is expressed in blood; brain; notochord; tail bud; and yolk syncytial layer. Orthologous to human AK3 (adenylate kinase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb845 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Gieger et al., 2011
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ak3 Human Ortholog

No data available

Associated With ak3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR033690	Adenylate kinase, conserved site
Domain	IPR007862	Adenylate kinase, active site lid domain
Family	IPR000850	Adenylate kinase/UMP-CMP kinase
Family	IPR006259	Adenylate kinase subfamily
Family	IPR028586	Adenylate kinase 3/4, mitochondrial
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036193	Adenylate kinase, active site lid domain superfamily