Gene
uqcrfs1
- ID
- ZDB-GENE-040426-2060
- Name
- ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
- Symbol
- uqcrfs1 Nomenclature History
- Previous Names
-
- fb78f10
- wu:fb05d11
- wu:fb78f10 (1)
- wu:fj05e12
- zgc:73109
- zgc:85614
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to contribute to ubiquinol-cytochrome-c reductase activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Predicted to localize to mitochondrial respiratory chain complex III. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency. Is expressed in several structures, including alar plate midbrain region; axis; hatching gland; optic tectum; and polster. Orthologous to several human genes including UQCRFS1 (ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73109 (1 image)
- IMAGE:6909161 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Mitochondrial complex III deficiency, nuclear type 10 | 618775 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004192 | Cytochrome b-c1 complex subunit Rieske, transmembrane domain |
| Domain | IPR005805 | Rieske iron-sulphur protein, C-terminal |
| Domain | IPR006317 | Ubiquinol-cytochrome c reductase, iron-sulphur subunit |
| Domain | IPR015248 | Ubiquinol-cytochrome c reductase iron-sulphur subunit, N-terminal |
| Domain | IPR017941 | Rieske [2Fe-2S] iron-sulphur domain |
| Family | IPR014349 | Rieske iron-sulphur protein |
| Homologous_superfamily | IPR011070 | Globular protein, non-globular alpha/beta subunit |
| Homologous_superfamily | IPR036922 | Rieske [2Fe-2S] iron-sulphur domain superfamily |
| Homologous_superfamily | IPR037008 | Cytochrome bc1 complex subunit Rieske, transmembrane domain superfamily |
Domain Details Per Protein
| Protein | Length | Cytochrome b-c1 complex subunit Rieske, transmembrane domain | Cytochrome bc1 complex subunit Rieske, transmembrane domain superfamily | Globular protein, non-globular alpha/beta subunit | Rieske [2Fe-2S] iron-sulphur domain | Rieske [2Fe-2S] iron-sulphur domain superfamily | Rieske iron-sulphur protein | Rieske iron-sulphur protein, C-terminal | Ubiquinol-cytochrome c reductase, iron-sulphur subunit | Ubiquinol-cytochrome c reductase iron-sulphur subunit, N-terminal |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A7MCR1
|
273 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
uqcrfs1-201
(1)
|
Ensembl | 3,965 nt |
Interactions and Pathways
No data available
Plasmids
No data available