Gene

dusp1

ID

ZDB-GENE-040426-2018

Name

dual specificity phosphatase 1

Symbol

dusp1 Nomenclature History

Previous Names

mkp-1 (1)
cb269 (1)
id:ibd2586
sb:cb269
wu:fd19g02
wu:fe50g09
zgc:55920

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have MAP kinase tyrosine/serine/threonine phosphatase activity. Predicted to be involved in endoderm formation and inactivation of MAPK activity. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in breast cancer. Is expressed in several structures, including forebrain neural keel; mesoderm; nervous system; neural tube; and tail bud. Orthologous to human DUSP1 (dual specificity phosphatase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

27 figures from 9 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb269 (18 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dusp1 Human Ortholog

No data available

Associated With dusp1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR016130	Protein-tyrosine phosphatase, active site
Domain	IPR000340	Dual specificity phosphatase, catalytic domain
Domain	IPR000387	Tyrosine-specific protein phosphatases domain
Domain	IPR001763	Rhodanese-like domain
Domain	IPR003595	Protein-tyrosine phosphatase, catalytic
Domain	IPR020422	Dual specificity protein phosphatase domain
Family	IPR008343	Mitogen-activated protein (MAP) kinase phosphatase
Homologous_superfamily	IPR029021	Protein-tyrosine phosphatase-like
Homologous_superfamily	IPR036873	Rhodanese-like domain superfamily

Domain Details Per Protein

Protein	Length	Dual specificity phosphatase, catalytic domain	Dual specificity protein phosphatase domain	Mitogen-activated protein (MAP) kinase phosphatase	Protein-tyrosine phosphatase, active site	Protein-tyrosine phosphatase, catalytic	Protein-tyrosine phosphatase-like	Rhodanese-like domain	Rhodanese-like domain superfamily	Tyrosine-specific protein phosphatases domain
UniProtKB:Q7ZVL8 InterPro	360

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dusp1-202 (1) Ensembl	Ensembl	2,326 nt	Select Tool ZFIN BLAST
ncRNA	dusp1-002 (1) Ensembl	Ensembl	545 nt	Select Tool ZFIN BLAST
ncRNA	dusp1-003 (1) Ensembl	Ensembl	715 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations