Gene
dusp1
- ID
- ZDB-GENE-040426-2018
- Name
- dual specificity phosphatase 1
- Symbol
- dusp1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to have MAP kinase tyrosine/serine/threonine phosphatase activity. Predicted to be involved in endoderm formation and inactivation of MAPK activity. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in breast cancer. Is expressed in several structures, including forebrain neural keel; mesoderm; nervous system; neural tube; and tail bud. Orthologous to human DUSP1 (dual specificity phosphatase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb269 (18 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000340 | Dual specificity phosphatase, catalytic domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR001763 | Rhodanese-like domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
| Domain | IPR020422 | Dual specificity protein phosphatase domain |
| Family | IPR008343 | Mitogen-activated protein (MAP) kinase phosphatase |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
| Homologous_superfamily | IPR036873 | Rhodanese-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Dual specificity phosphatase, catalytic domain | Dual specificity protein phosphatase domain | Mitogen-activated protein (MAP) kinase phosphatase | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Rhodanese-like domain | Rhodanese-like domain superfamily | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZVL8
|
360 |
Interactions and Pathways
No data available
Plasmids
No data available