Gene
sucla2
- ID
- ZDB-GENE-040426-1963
- Name
- succinate-CoA ligase ADP-forming subunit beta
- Symbol
- sucla2 Nomenclature History
- Previous Names
-
- wu:fb18c11
- wu:fj38c11
- wu:fj90d07
- zgc:73397
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have succinate-CoA ligase (ADP-forming) activity. Predicted to be involved in succinyl-CoA metabolic process and tricarboxylic acid cycle. Predicted to localize to mitochondrion and succinate-CoA ligase complex. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 5. Is expressed in several structures, including axis; hatching gland; mesoderm; musculature system; and solid lens vesicle. Orthologous to human SUCLA2 (succinate-CoA ligase ADP-forming subunit beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73397 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Gut et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| mitochondrial DNA depletion syndrome 5 | Alliance | Mitochondrial DNA depletion syndrome 5 (encephalomyopathic with or without methylmalonic aciduria) | 612073 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017866 | Succinyl-CoA synthetase, beta subunit, conserved site |
| Domain | IPR005811 | ATP-citrate synthase/succinyl-CoA ligase, C-terminal domain |
| Domain | IPR013650 | ATP-grasp fold, succinyl-CoA synthetase-type |
| Family | IPR005809 | Succinate--CoA ligase-like, beta subunit |
| Family | IPR034723 | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial |
| Homologous_superfamily | IPR013815 | ATP-grasp fold, subdomain 1 |
| Homologous_superfamily | IPR016102 | Succinyl-CoA synthetase-like |
Domain Details Per Protein
| Protein | Length | ATP-citrate synthase/succinyl-CoA ligase, C-terminal domain | ATP-grasp fold, subdomain 1 | ATP-grasp fold, succinyl-CoA synthetase-type | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial | Succinate--CoA ligase-like, beta subunit | Succinyl-CoA synthetase, beta subunit, conserved site | Succinyl-CoA synthetase-like |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6PBI0
|
466 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sucla2-201
(1)
|
Ensembl | 2,111 nt | ||
| mRNA |
sucla2-202
(1)
|
Ensembl | 719 nt |
Interactions and Pathways
No data available
Plasmids
No data available