Gene
sar1b
- ID
- ZDB-GENE-040426-1958
- Name
- secretion associated, Ras related GTPase 1B
- Symbol
- sar1b Nomenclature History
- Previous Names
-
- sara2
- zgc:73204
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activity. Acts upstream of or within several processes, including embryonic viscerocranium morphogenesis; intestinal cholesterol absorption; and organ growth. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Is expressed in blastomere; digestive system; nervous system; pharyngeal arch; and primary germ layer. Used to study chylomicron retention disease. Human ortholog(s) of this gene implicated in chylomicron retention disease. Orthologous to human SAR1B (secretion associated Ras related GTPase 1B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Levic et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Levic et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| chylomicron retention disease | Alliance | Chylomicron retention disease | 246700 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| chylomicron retention disease | AB + MO1-sar1b | control | Levic et al., 2015 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | P-loop containing nucleoside triphosphate hydrolase | Small GTPase superfamily, ARF/SAR type | Small GTPase superfamily, SAR1-type | Small GTP-binding domain |
|---|---|---|---|---|---|
|
UniProtKB:Q6PBX2
|
198 |
Interactions and Pathways
No data available
Plasmids
No data available