Gene

katnb1

ID

ZDB-GENE-040426-1954

Name

katanin p80 (WD repeat containing) subunit B 1

Symbol

katnb1 Nomenclature History

Previous Names

wu:fj32f02
wu:fj65h01 (1)
zgc:56071

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to contribute to microtubule-severing ATPase activity. Involved in midbrain development. Predicted to localize to cytoplasm; katanin complex; and spindle pole. Human ortholog(s) of this gene implicated in lissencephaly. Is expressed in brain and pectoral fin. Orthologous to human KATNB1 (katanin regulatory subunit B1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7139857 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With katnb1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
lissencephaly 6	Alliance	Lissencephaly 6, with microcephaly	616212

Associated With katnb1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
idiopathic scoliosis	katnb1^mh102/mh102	standard conditions	Meyer-Miner et al., 2022

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019775	WD40 repeat, conserved site
Domain	IPR028021	Katanin p80 subunit, C-terminal
Family	IPR026962	Katanin p80 WD40 repeat-containing subunit B1
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat
Repeat	IPR020472	G-protein beta WD-40 repeat

Domain Details Per Protein

Protein	Length	G-protein beta WD-40 repeat	Katanin p80 subunit, C-terminal	Katanin p80 WD40 repeat-containing subunit B1	WD40 repeat	WD40 repeat, conserved site	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:Q7ZUV2 InterPro	694

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	katnb1-201 (1) Ensembl	Ensembl	2,572 nt	Select Tool
mRNA	katnb1-202 (1) Ensembl	Ensembl	769 nt	Select Tool
mRNA	katnb1-203 (1) Ensembl	Ensembl	741 nt	Select Tool
mRNA	katnb1-206 (1) Ensembl	Ensembl	1,050 nt	Select Tool
ncRNA	katnb1-004 (1) Ensembl	Ensembl	542 nt	Select Tool
ncRNA	katnb1-005 (1) Ensembl	Ensembl	701 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations