Gene
dnaaf4
- ID
- ZDB-GENE-040426-1892
- Name
- dynein axonemal assembly factor 4
- Symbol
- dnaaf4 Nomenclature History
- Previous Names
-
- dyx1c1
- zgc:77853
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have estrogen receptor binding activity. Involved in cilium assembly; epithelial cilium movement involved in determination of left/right asymmetry; and left/right axis specification. Predicted to localize to centrosome and non-motile cilium. Human ortholog(s) of this gene implicated in dyslexia and primary ciliary dyskinesia 25. Is expressed in several structures, including Kupffer's vesicle; forerunner cell group; nervous system; neural tube; and pleuroperitoneal region. Orthologous to human DNAAF4 (dynein axonemal assembly factor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77853 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary ciliary dyskinesia 25 | Alliance | Ciliary dyskinesia, primary, 25 | 615482 |
| {Dyslexia, susceptibility to, 1} | 127700 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR007052 | CS domain |
| Domain | IPR037894 | Dynein axonemal assembly factor 4, CS domain |
| Family | IPR052004 | Axonemal Dynein Assembly Factor 4 |
| Homologous_superfamily | IPR008978 | HSP20-like chaperone |
| Homologous_superfamily | IPR011990 | Tetratricopeptide-like helical domain superfamily |
| Repeat | IPR019734 | Tetratricopeptide repeat |
Domain Details Per Protein
| Protein | Length | Axonemal Dynein Assembly Factor 4 | CS domain | Dynein axonemal assembly factor 4, CS domain | HSP20-like chaperone | Tetratricopeptide-like helical domain superfamily | Tetratricopeptide repeat |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6P010
|
420 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available