Gene
grhprb
- ID
- ZDB-GENE-040426-1847
- Name
- glyoxylate reductase/hydroxypyruvate reductase b
- Symbol
- grhprb Nomenclature History
- Previous Names
-
- fb80f04
- wu:fb80f04
- zgc:77636
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have glycerate dehydrogenase activity; glyoxylate reductase (NADP) activity; and hydroxypyruvate reductase activity. Predicted to be involved in oxidation-reduction process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in primary hyperoxaluria and primary hyperoxaluria type 2. Is expressed in liver; pronephric duct; pronephros; and yolk syncytial layer. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77636 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary hyperoxaluria type 2 | Alliance | Hyperoxaluria, primary, type II | 260000 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR029752 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 |
| Conserved_site | IPR029753 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site |
| Domain | IPR006139 | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain |
| Domain | IPR006140 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain |
| Family | IPR050223 | D-isomer specific 2-hydroxyacid dehydrogenase |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | D-isomer specific 2-hydroxyacid dehydrogenase | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site | D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 | NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:E9QCX2
|
351 | ||||||
|
UniProtKB:Q6P0V7
|
336 | ||||||
|
UniProtKB:F1QYH7
|
361 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
grhprb-201
(1)
|
Ensembl | 1,276 nt | ||
| mRNA |
grhprb-202
(1)
|
Ensembl | 733 nt | ||
| mRNA |
grhprb-205
(1)
|
Ensembl | 2,454 nt | ||
| ncRNA |
grhprb-004
(1)
|
Ensembl | 426 nt | ||
| ncRNA |
grhprb-006
(1)
|
Ensembl | 1,068 nt |
Interactions and Pathways
No data available
Plasmids
No data available