Gene
bace1
- ID
- ZDB-GENE-040426-1835
- Name
- beta-secretase 1
- Symbol
- bace1 Nomenclature History
- Previous Names
-
- zgc:77409
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable aspartic-type endopeptidase activity. Acts upstream of or within myelination in peripheral nervous system and positive regulation of myelination. Predicted to be located in several cellular components, including endosome; lysosome; and membrane raft. Is expressed in brain. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE1 (beta-secretase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from van Bebber et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR001969 | Aspartic peptidase, active site |
| Domain | IPR033121 | Peptidase family A1 domain |
| Domain | IPR033874 | Memapsin-like |
| Family | IPR001461 | Aspartic peptidase A1 |
| Family | IPR009119 | Beta-secretase BACE |
| Family | IPR009120 | Beta-secretase BACE1 |
| Homologous_superfamily | IPR021109 | Aspartic peptidase domain superfamily |
Domain Details Per Protein
| Protein | Length | Aspartic peptidase A1 | Aspartic peptidase, active site | Aspartic peptidase domain superfamily | Beta-secretase BACE | Beta-secretase BACE1 | Memapsin-like | Peptidase family A1 domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6NZT7
|
505 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available