Gene
hnrnpa1a
- ID
- ZDB-GENE-040426-1546
- Name
- heterogeneous nuclear ribonucleoprotein A1a
- Symbol
- hnrnpa1a Nomenclature History
- Previous Names
-
- zgc:66127 (1)
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Enables mRNA 3'-UTR binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of catalytic step 2 spliceosome. Is expressed in gut; head; nervous system; and trunk. Human ortholog(s) of this gene implicated in HTLV-1-associated myelopathy/tropical spastic paraparesis; amyotrophic lateral sclerosis type 20; distal myopathy 3; and inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3. Orthologous to human HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:66127 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amyotrophic lateral sclerosis type 20 | Alliance | Amyotrophic lateral sclerosis 20 | 615426 |
| distal myopathy 3 | Alliance | ?Myopathy, distal, 3 | 610099 |
| inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3 | Alliance | ?Inclusion body myopathy with early-onset Paget disease without frontotemporal dementia 3 | 615424 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | hnRNP A1, RNA recognition motif 1 | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA recognition motif domain |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QLI0 | InterPro | 439 | ||||
| UniProtKB:Q7SXQ3 | InterPro | 388 | ||||
| UniProtKB:A0A8M9PUQ8 | InterPro | 411 | ||||
| UniProtKB:A0A8M9QHJ0 | InterPro | 417 | ||||
| UniProtKB:A0A8M9QCY6 | InterPro | 445 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hnrnpa1a-201
(1)
|
Ensembl | 1,167 nt |
Interactions and Pathways
No data available
Plasmids
No data available