Gene
abcc2
- ID
- ZDB-GENE-040426-1523
- Name
- ATP-binding cassette, sub-family C (CFTR/MRP), member 2
- Symbol
- abcc2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable ATPase-coupled transmembrane transporter activity. Acts upstream of or within cell redox homeostasis. Predicted to be located in membrane. Predicted to be active in apical plasma membrane. Human ortholog(s) of this gene implicated in bile duct disease (multiple); bilirubin metabolic disorder (multiple); leukemia (multiple); liver disease (multiple); and lung non-small cell carcinoma. Orthologous to human ABCC2 (ATP binding cassette subfamily C member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Dubin-Johnson syndrome | Alliance | Dubin-Johnson syndrome | 237500 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017871 | ABC transporter-like, conserved site |
| Domain | IPR003439 | ABC transporter-like, ATP-binding domain |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR011527 | ABC transporter type 1, transmembrane domain |
| Family | IPR005292 | Multi drug resistance-associated protein |
| Family | IPR050173 | ATP-binding cassette transporter C-like |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036640 | ABC transporter type 1, transmembrane domain superfamily |
Domain Details Per Protein
| Protein | Length | AAA+ ATPase domain | ABC transporter-like, ATP-binding domain | ABC transporter-like, conserved site | ABC transporter type 1, transmembrane domain | ABC transporter type 1, transmembrane domain superfamily | ATP-binding cassette transporter C-like | Multi drug resistance-associated protein | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1DB26
|
1567 |
Interactions and Pathways
No data available
Plasmids
No data available