Gene
irf7
- ID
- ZDB-GENE-040426-1518
- Name
- interferon regulatory factor 7
- Symbol
- irf7 Nomenclature History
- Previous Names
-
- wu:fl24c03
- zgc:66043
- zgc:77947
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Exhibits transcription regulatory region DNA binding activity. Involved in hemopoiesis; regulation of hemopoiesis; and response to virus. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is expressed in alar plate midbrain region; nervous system; otic vesicle; pronephric duct; and ventral wall of dorsal aorta. Orthologous to human IRF7 (interferon regulatory factor 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77947 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Hu et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 39 | Alliance | ?Immunodeficiency 39 | 616345 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001346 | Interferon regulatory factor, DNA-binding domain |
| Domain | IPR019471 | Interferon regulatory factor-3 |
| Homologous_superfamily | IPR008984 | SMAD/FHA domain superfamily |
| Homologous_superfamily | IPR017855 | SMAD-like domain superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Interferon regulatory factor-3 | Interferon regulatory factor, DNA-binding domain | SMAD/FHA domain superfamily | SMAD-like domain superfamily | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QNG2
|
422 | ||||||
|
UniProtKB:H0WFC4
|
377 |
Interactions and Pathways
No data available
Plasmids
No data available