Gene
cdkal1
- ID
- ZDB-GENE-040426-1443
- Name
- CDK5 regulatory subunit associated protein 1-like 1
- Symbol
- cdkal1 Nomenclature History
- Previous Names
-
- zgc:65864
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have N6-threonylcarbomyladenosine methylthiotransferase activity. Involved in pancreas regeneration and type B pancreatic cell development. Predicted to localize to endoplasmic reticulum. Human ortholog(s) of this gene implicated in diabetes mellitus; gestational diabetes; and type 2 diabetes mellitus. Orthologous to human CDKAL1 (CDK5 regulatory subunit associated protein 1 like 1).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:65864 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from O'Hare et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR020612 | Methylthiotransferase, conserved site |
Domain | IPR002792 | TRAM domain |
Domain | IPR006638 | Elp3/MiaA/NifB-like, radical SAM core domain |
Domain | IPR007197 | Radical SAM |
Domain | IPR013848 | Methylthiotransferase, N-terminal |
Family | IPR005839 | Methylthiotransferase |
Family | IPR006466 | MiaB-like tRNA modifying enzyme, archaea/eukaryota |
Homologous_superfamily | IPR023404 | Radical SAM, alpha/beta horseshoe |
Homologous_superfamily | IPR038135 | Methylthiotransferase, N-terminal domain superfamily |
Domain Details Per Protein
Protein | Length | Elp3/MiaA/NifB-like, radical SAM core domain | Methylthiotransferase | Methylthiotransferase, conserved site | Methylthiotransferase, N-terminal | Methylthiotransferase, N-terminal domain superfamily | MiaB-like tRNA modifying enzyme, archaea/eukaryota | Radical SAM | Radical SAM, alpha/beta horseshoe | TRAM domain |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q6PG34
|
547 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available