Gene
ptpn12
- ID
- ZDB-GENE-040426-1441
- Name
- protein tyrosine phosphatase non-receptor type 12
- Symbol
- ptpn12 Nomenclature History
- Previous Names
-
- zgc:65856
- zgc:77437
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable protein tyrosine phosphatase activity. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in cytoplasm. Is expressed in several structures, including immature eye; nervous system; neural tube; pectoral fin musculature; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human PTPN12 (protein tyrosine phosphatase non-receptor type 12).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:65856 (6 images)
- MGC:77437 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Duffy et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | Colon cancer, somatic | 114500 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000242 | Tyrosine-specific protein phosphatase, PTPase domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
| Domain | IPR047251 | Protein-tyrosine phosphatase non-receptor type-12, catalytic domain |
| Family | IPR012266 | Tyrosine-protein phosphatase non-receptor type 12 |
| Family | IPR047170 | Tyrosine-protein phosphatase non-receptor type 12/18/22 |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
Domain Details Per Protein
| Protein | Length | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Protein-tyrosine phosphatase non-receptor type-12, catalytic domain | Tyrosine-protein phosphatase non-receptor type 12 | Tyrosine-protein phosphatase non-receptor type 12/18/22 | Tyrosine-specific protein phosphatase, PTPase domain | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6PEI4
|
570 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptpn12-201
(1)
|
Ensembl | 510 nt |
Interactions and Pathways
No data available
Plasmids
No data available