Gene

stn1

ID

ZDB-GENE-040426-1390

Name

STN1 subunit of CST complex

Symbol

stn1 Nomenclature History

Previous Names

obfc1
zgc:64174 (1)

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have single-stranded telomeric DNA binding activity. Involved in vasculature development. Predicted to localize to DNA replication factor A complex; nuclear chromosome, telomeric region; and site of double-strand break. Used to study telangiectasis. Orthologous to human STN1 (STN1 subunit of CST complex).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:64174 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Simon et al., 2016
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With stn1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Cerebroretinal microangiopathy with calcifications and cysts 2	617341

Associated With stn1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
telangiectasis	AB + MO1-stn1	standard conditions	Simon et al., 2016

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR015253	Stn1, C-terminal
Domain	IPR018856	CST complex subunit Stn1, N-terminal
Family	IPR014647	CST complex subunit Stn1
Family	IPR040260	Replication factor A protein-like
Homologous_superfamily	IPR012340	Nucleic acid-binding, OB-fold
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily
Homologous_superfamily	IPR042082	CST complex subunit Stn1, wHTH1 motif superfamily