Gene

stn1

ID

ZDB-GENE-040426-1390

Name

STN1 subunit of CST complex

Symbol

stn1 Nomenclature History

Previous Names

obfc1
zgc:64174 (1)

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable single-stranded telomeric DNA binding activity. Acts upstream of or within vasculature development. Predicted to be located in chromosome, telomeric region and nucleus. Predicted to be part of CST complex. Used to study telangiectasis. Human ortholog(s) of this gene implicated in melanoma. Orthologous to human STN1 (STN1 subunit of CST complex).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:64174 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Simon et al., 2016
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With stn1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Cerebroretinal microangiopathy with calcifications and cysts 2	617341

Associated With stn1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
telangiectasis	AB + MO1-stn1	standard conditions	Simon et al., 2016

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR015253	Stn1, C-terminal
Domain	IPR018856	CST complex subunit Stn1, N-terminal
Family	IPR014647	CST complex subunit Stn1
Family	IPR040260	Replication factor A protein-like
Homologous_superfamily	IPR012340	Nucleic acid-binding, OB-fold
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily
Homologous_superfamily	IPR042082	CST complex subunit Stn1, wHTH1 motif superfamily