Gene
lipca
- ID
- ZDB-GENE-040426-1361
- Name
- lipase, hepatic a
- Symbol
- lipca Nomenclature History
- Previous Names
-
- lipc
- zgc:64081
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have apolipoprotein binding activity and lipase activity. Involved in response to hormone. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; coronary artery disease; familial combined hyperlipidemia; peripheral vascular disease; and type 2 diabetes mellitus. Is expressed in several structures, including heart; integument; lens; liver; and pleuroperitoneal region. Orthologous to human LIPC (lipase C, hepatic type).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 13 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64081 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
type 2 diabetes mellitus | Alliance | {Diabetes mellitus, noninsulin-dependent} | 125853 |
Hepatic lipase deficiency | 614025 | ||
[High density lipoprotein cholesterol level QTL 12] | 612797 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR001024 | PLAT/LH2 domain |
Domain | IPR013818 | Lipase |
Domain | IPR033906 | Lipase, N-terminal |
Family | IPR000734 | Triacylglycerol lipase family |
Family | IPR002333 | Hepatic lipase |
Family | IPR016272 | Lipase, LIPH-type |
Homologous_superfamily | IPR029058 | Alpha/Beta hydrolase fold |
Homologous_superfamily | IPR036392 | PLAT/LH2 domain superfamily |
Domain Details Per Protein
Protein | Length | Alpha/Beta hydrolase fold | Hepatic lipase | Lipase | Lipase, LIPH-type | Lipase, N-terminal | PLAT/LH2 domain | PLAT/LH2 domain superfamily | Triacylglycerol lipase family |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q7T359
|
514 |
Interactions and Pathways
No data available
Plasmids
No data available