Gene

xpa

ID

ZDB-GENE-040426-1205

Name

xeroderma pigmentosum, complementation group A

Symbol

xpa Nomenclature History

Previous Names

zgc:63640

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable damaged DNA binding activity. Predicted to be involved in DNA repair. Predicted to act upstream of or within DNA repair. Predicted to be located in nucleus. Predicted to be part of nucleotide-excision repair factor 1 complex. Is expressed in liver and telencephalon. Human ortholog(s) of this gene implicated in xeroderma pigmentosum and xeroderma pigmentosum group A. Orthologous to human XPA (XPA, DNA damage recognition and repair factor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With xpa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
xeroderma pigmentosum group A	Alliance	Xeroderma pigmentosum, group A	278700

Associated With xpa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR022652	Zinc finger, XPA-type, conserved site
Domain	IPR022656	XPA, C-terminal
Domain	IPR027838	Domain of unknown function DUF4585
Family	IPR000465	XPA/RAD14
Homologous_superfamily	IPR009061	Putative DNA-binding domain superfamily
Homologous_superfamily	IPR037129	XPA domain superfamily