Gene

pik3cd

ID

ZDB-GENE-040426-1128

Name

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta

Symbol

pik3cd Nomenclature History

Previous Names

zgc:63473 (1)

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in regulation of collateral sprouting in absence of injury. Predicted to localize to cytoplasm; phosphatidylinositol 3-kinase complex; and plasma membrane. Human ortholog(s) of this gene implicated in colorectal cancer; endometrial cancer; and primary immunodeficiency disease. Is expressed in central nervous system and cranial ganglion. Orthologous to human PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:63473 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Schmidt et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pik3cd Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
immunodeficiency 14	Alliance	Immunodeficiency 14A, autosomal dominant	615513
		Immunodeficiency 14B, autosomal recessive	619281
		?Roifman-Chitayat syndrome, digenic	613328

Associated With pik3cd Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site
Domain	IPR000341	Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
Domain	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain
Domain	IPR001263	Phosphoinositide 3-kinase, accessory (PIK) domain
Domain	IPR002420	C2 phosphatidylinositol 3-kinase-type domain
Domain	IPR003113	Phosphatidylinositol 3-kinase, adaptor-binding domain
Domain	IPR037703	PI3Kdelta, catalytic domain
Family	IPR015433	Phosphatidylinositol kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR036940	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
Homologous_superfamily	IPR042236	Phosphoinositide 3-kinase, accessory (PIK) domain superfamily

Domain Details Per Protein

Protein	Length	Armadillo-type fold	C2 domain superfamily	C2 phosphatidylinositol 3-kinase-type domain	Phosphatidylinositol 3-/4-kinase, catalytic domain	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily	Phosphatidylinositol 3/4-kinase, conserved site	Phosphatidylinositol 3-kinase, adaptor-binding domain	Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain	Phosphatidylinositol kinase	Phosphoinositide 3-kinase, accessory (PIK) domain	Phosphoinositide 3-kinase, accessory (PIK) domain superfamily	PI3Kdelta, catalytic domain	Protein kinase-like domain superfamily	Ubiquitin-like domain superfamily
UniProtKB:Q7SYE7 InterPro	1039

Transcripts

Genome Browsers

NCBI

No data available

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations