Gene
chuk
- ID
- ZDB-GENE-040426-1069
- Name
- component of inhibitor of nuclear factor kappa B kinase complex
- Symbol
- chuk Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable protein heterodimerization activity; protein homodimerization activity; and protein serine/threonine kinase activity. Predicted to contribute to IkappaB kinase activity. Acts upstream of or within several processes, including epiboly involved in gastrulation with mouth forming second; negative regulation of I-kappaB kinase/NF-kappaB signaling; and somite specification. Predicted to be located in nucleus. Predicted to be part of IkappaB kinase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including immature eye; nervous system; notochord; pectoral fin; and segmental plate. Human ortholog(s) of this gene implicated in fetal encasement syndrome; liver cancer; and prostate cancer. Orthologous to human CHUK (component of inhibitor of nuclear factor kappa B kinase complex).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56539 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Fukazawa et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| fetal encasement syndrome | Alliance | ?Cocoon syndrome | 613630 |
| ?Popliteal pterygium syndrome, Bartsocas-Papas type 2 | 619339 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR022007 | I-kappa-kinase-beta NEMO binding domain |
| Domain | IPR041185 | IKBKB, scaffold dimerization domain |
| Family | IPR051180 | Inhibitor of nuclear factor kappa-B kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR046375 | IKBKB, scaffold dimerization domain superfamily |
Domain Details Per Protein
| Protein | Length | I-kappa-kinase-beta NEMO binding domain | IKBKB, scaffold dimerization domain | IKBKB, scaffold dimerization domain superfamily | Inhibitor of nuclear factor kappa-B kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q4G3H4
|
758 |
Interactions and Pathways
No data available
Plasmids