Gene
chuk
- ID
- ZDB-GENE-040426-1069
- Name
- component of inhibitor of nuclear factor kappa B kinase complex
- Symbol
- chuk Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to contribute to IkappaB kinase activity. Involved in several processes, including I-kappaB kinase/NF-kappaB signaling; epiboly involved in gastrulation with mouth forming second; and somite specification. Predicted to localize to IkappaB kinase complex. Human ortholog(s) of this gene implicated in cocoon syndrome and prostate cancer. Is expressed in several structures, including immature eye; nervous system; notochord; pectoral fin; and segmental plate. Orthologous to human CHUK (component of inhibitor of nuclear factor kappa B kinase complex).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56539 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Fukazawa et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| fetal encasement syndrome | Alliance | ?Cocoon syndrome | 613630 |
| ?Popliteal pterygium syndrome, Bartsocas-Papas type 2 | 619339 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR022007 | I-kappa-kinase-beta NEMO binding domain |
| Domain | IPR041185 | IKBKB, scaffold dimerization domain |
| Family | IPR051180 | Inhibitor of nuclear factor kappa-B kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR046375 | IKBKB, scaffold dimerization domain superfamily |
Domain Details Per Protein
| Protein | Length | I-kappa-kinase-beta NEMO binding domain | IKBKB, scaffold dimerization domain | IKBKB, scaffold dimerization domain superfamily | Inhibitor of nuclear factor kappa-B kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q4G3H4
|
758 |
Interactions and Pathways
No data available
Plasmids