Gene

sh2d3cb

ID

ZDB-GENE-040426-1052

Name

SH2 domain containing 3Cb

Symbol

sh2d3cb Nomenclature History

Previous Names

sh2d3c
zgc:56490 (1)

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of peptidyl-serine phosphorylation. Is expressed in nervous system; neural tube; and trigeminal placode. Orthologous to human SH2D3C (SH2 domain containing 3C).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56490 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sh2d3cb Human Ortholog

No data available

Associated With sh2d3cb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000980	SH2 domain
Domain	IPR001895	Ras guanine-nucleotide exchange factors catalytic domain
Domain	IPR044102	SHEP1/BCAR3/NSP1, SH2 domain
Family	IPR051853	Adapter protein with SH2 and Ras-GEF domains
Homologous_superfamily	IPR023578	Ras guanine nucleotide exchange factor domain superfamily
Homologous_superfamily	IPR036860	SH2 domain superfamily
Homologous_superfamily	IPR036964	Ras guanine-nucleotide exchange factor, catalytic domain superfamily

Domain Details Per Protein

Protein	Length	Adapter protein with SH2 and Ras-GEF domains	Ras guanine-nucleotide exchange factor, catalytic domain superfamily	Ras guanine nucleotide exchange factor domain superfamily	Ras guanine-nucleotide exchange factors catalytic domain	SH2 domain	SH2 domain superfamily	SHEP1/BCAR3/NSP1, SH2 domain
UniProtKB:A0A8M2BCW0 InterPro	629
UniProtKB:Q7ZUD0 InterPro	635

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	sh2d3cb-201 (1) Ensembl	Ensembl	659 nt	Select Tool
mRNA	sh2d3cb-202 (1) Ensembl	Ensembl	694 nt	Select Tool
mRNA	sh2d3cb-203 (1) Ensembl	Ensembl	2,537 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations