Gene
hmgcs1
- ID
- ZDB-GENE-040426-1042
- Name
- 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
- Symbol
- hmgcs1 Nomenclature History
- Previous Names
-
- zgc:56481 (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have hydroxymethylglutaryl-CoA synthase activity. Involved in embryonic viscerocranium morphogenesis; neural crest cell differentiation; and oligodendrocyte development. Is expressed in several structures, including digestive system; immature eye; nervous system; pectoral fin musculature; and yolk syncytial layer. Orthologous to several human genes including HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 30 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56481 (21 images)
Wild Type Expression Summary
- All Phenotype Data
- 16 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR000590 | Hydroxymethylglutaryl-coenzyme A synthase, active site |
| Domain | IPR013528 | Hydroxymethylglutaryl-coenzyme A synthase, N-terminal |
| Domain | IPR013746 | Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain |
| Family | IPR010122 | Hydroxymethylglutaryl-CoA synthase, eukaryotic |
| Homologous_superfamily | IPR016039 | Thiolase-like |
Domain Details Per Protein
| Protein | Length | Hydroxymethylglutaryl-CoA synthase, eukaryotic | Hydroxymethylglutaryl-coenzyme A synthase, active site | Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain | Hydroxymethylglutaryl-coenzyme A synthase, N-terminal | Thiolase-like |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IQG1
|
519 | |||||
|
UniProtKB:A0A8M1PIL7
|
526 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hmgcs1-201
(1)
|
Ensembl | 688 nt | ||
| mRNA |
hmgcs1-202
(1)
|
Ensembl | 643 nt | ||
| mRNA |
hmgcs1-203
(1)
|
Ensembl | 986 nt | ||
| mRNA |
hmgcs1-204
(1)
|
Ensembl | 3,182 nt | ||
| mRNA |
hmgcs1-205
(1)
|
Ensembl | 1,699 nt |
Interactions and Pathways
No data available
Plasmids
No data available