Gene

eif2b3

ID

ZDB-GENE-040426-1039

Name

eukaryotic translation initiation factor 2B, subunit 3 gamma

Symbol

eif2b3 Nomenclature History

Previous Names

zgc:56473 (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have guanyl-nucleotide exchange factor activity and translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation. Predicted to localize to eukaryotic translation initiation factor 2B complex and guanyl-nucleotide exchange factor complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Is expressed in eye and gut. Orthologous to human EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6909645 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 12 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With eif2b3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
leukoencephalopathy with vanishing white matter 3	Alliance	Leukoencephalopathy with vanishing white matter 3, with or without ovarian failure	620313

Associated With eif2b3 Via Experimental Models

Human Disease	Fish	Conditions	Citations
leukoencephalopathy with vanishing white matter	eif2b3^{ck156a/ck156a}	standard conditions	(2)

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005835	Nucleotidyl transferase domain
Family	IPR051960	Eukaryotic Initiation Factor 2B Subunit Gamma
Homologous_superfamily	IPR029044	Nucleotide-diphospho-sugar transferases

Domain Details Per Protein

Protein	Length	Eukaryotic Initiation Factor 2B Subunit Gamma	Nucleotide-diphospho-sugar transferases	Nucleotidyl transferase domain
UniProtKB:Q7ZTY5 InterPro	453

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	eif2b3-201 (1) Ensembl	Ensembl	1,737 nt	Select Tool
mRNA	eif2b3-202 (1) Ensembl	Ensembl	698 nt	Select Tool
mRNA	eif2b3-203 (1) Ensembl	Ensembl	2,342 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations