Gene

alpl

ID

ZDB-GENE-040420-1

Name

alkaline phosphatase, biomineralization associated

Symbol

alpl Nomenclature History

Previous Names

alp (1)
zgc:56672

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to have alkaline phosphatase activity. Involved in response to mechanical stimulus. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; infantile hypophosphatasia; and uremia. Is expressed in several structures, including anterior neural keel; bone element; central nervous system; gut; and vasculature. Orthologous to human ALPL (alkaline phosphatase, biomineralization associated).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

41 figures from 30 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56672 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With alpl Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
adult hypophosphatasia	Alliance	Hypophosphatasia, adult	146300
adult hypophosphatasia	Alliance	Odontohypophosphatasia	146300
childhood hypophosphatasia	Alliance	Hypophosphatasia, childhood	241510
infantile hypophosphatasia	Alliance	Hypophosphatasia, infantile	241500

Associated With alpl Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR018299	Alkaline phosphatase, active site
Family	IPR001952	Alkaline phosphatase
Homologous_superfamily	IPR017850	Alkaline-phosphatase-like, core domain superfamily