Gene
alpl
- ID
- ZDB-GENE-040420-1
- Name
- alkaline phosphatase, biomineralization associated
- Symbol
- alpl Nomenclature History
- Previous Names
-
- alp (1)
- zgc:56672
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have alkaline phosphatase activity. Involved in response to mechanical stimulus. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; infantile hypophosphatasia; and uremia. Is expressed in several structures, including anterior neural keel; bone element; central nervous system; gut; and vasculature. Orthologous to human ALPL (alkaline phosphatase, biomineralization associated).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 41 figures from 30 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56672 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| adult hypophosphatasia | Alliance | Hypophosphatasia, adult | 146300 |
| adult hypophosphatasia | Alliance | Odontohypophosphatasia | 146300 |
| childhood hypophosphatasia | Alliance | Hypophosphatasia, childhood | 241510 |
| infantile hypophosphatasia | Alliance | Hypophosphatasia, infantile | 241500 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Alkaline phosphatase | Alkaline phosphatase, active site | Alkaline-phosphatase-like, core domain superfamily |
|---|---|---|---|---|
|
UniProtKB:F1Q5B5
|
561 | |||
|
UniProtKB:A0A8M9PUR2
|
554 | |||
|
UniProtKB:A0A8M2BGI2
|
527 |
Interactions and Pathways
No data available
Plasmids
No data available