Gene
mnx1
- ID
- ZDB-GENE-040409-1
- Name
- motor neuron and pancreas homeobox 1
- Symbol
- mnx1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity. Involved in spinal cord motor neuron cell fate specification and type B pancreatic cell differentiation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Currarino syndrome. Is expressed in several structures, including central nervous system; endoderm; mesoderm; neurons; and pancreatic system. Orthologous to human MNX1 (motor neuron and pancreas homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 39 figures from 26 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Currarino syndrome | Alliance | Currarino syndrome | 176450 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeobox protein MNX1/Ceh-12 | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|---|
|
UniProtKB:Q6SYZ1
|
311 |
Interactions and Pathways
No data available
Plasmids