Gene
pik3r2
- ID
- ZDB-GENE-040309-1
- Name
- phosphoinositide-3-kinase, regulatory subunit 2 (beta)
- Symbol
- pik3r2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in insulin receptor signaling pathway; phosphatidylinositol phosphorylation; and regulation of phosphatidylinositol 3-kinase activity. Predicted to localize to phosphatidylinositol 3-kinase complex. Human ortholog(s) of this gene implicated in pancreatic ductal adenocarcinoma. Orthologous to human PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 | 603387 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000198 | Rho GTPase-activating protein domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR032498 | PI3K regulatory subunit p85-related , inter-SH2 domain |
| Domain | IPR035020 | PI3K p85 subunit, C-terminal SH2 domain |
| Domain | IPR035022 | PI3K p85 subunit, N-terminal SH2 domain |
| Domain | IPR035586 | Phosphatidylinositol 3-kinase regulatory subunit beta, SH3 domain |
| Homologous_superfamily | IPR008936 | Rho GTPase activation protein |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | Phosphatidylinositol 3-kinase regulatory subunit beta, SH3 domain | PI3K p85 subunit, C-terminal SH2 domain | PI3K p85 subunit, N-terminal SH2 domain | PI3K regulatory subunit p85-related , inter-SH2 domain | Rho GTPase-activating protein domain | Rho GTPase activation protein | SH2 domain | SH2 domain superfamily | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B3DHG9
|
724 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pik3r2-201
(1)
|
Ensembl | 9,125 nt | ||
| mRNA |
pik3r2-202
(1)
|
Ensembl | 2,568 nt |
Interactions and Pathways
No data available
Plasmids
No data available