Gene

tlr3

ID

ZDB-GENE-040219-7

Name

toll-like receptor 3

Symbol

tlr3 Nomenclature History

Previous Names

zgc:123006

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable signaling receptor activity. Acts upstream of or within response to bacterium and response to virus. Predicted to be located in cytoplasm and membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including blood; central nervous system; immature eye; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; human immunodeficiency virus infectious disease; liver cirrhosis; and primary immunodeficiency disease (multiple). Orthologous to human TLR3 (toll like receptor 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

24 figures from 15 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu558 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Graber et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tlr3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{HIV1 infection, resistance to}	609423
		{Immunodeficiency 83, susceptibility to viral infections}	613002

Associated With tlr3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain
Domain	IPR000483	Cysteine-rich flanking region, C-terminal
Domain	IPR041015	Toll-like receptor 3 trans-membrane domain
Family	IPR017241	Toll-like receptor
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Homologous_superfamily	IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR003591	Leucine-rich repeat, typical subtype