Gene

tlr2

ID

ZDB-GENE-040219-6

Name

toll-like receptor 2

Symbol

tlr2 Nomenclature History

Previous Names

TIR2 (1)

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable signaling receptor activity and triacyl lipopeptide binding activity. Acts upstream of or within activation of immune response and immune response. Predicted to be located in cytoplasm and membrane. Predicted to be active in plasma membrane. Is expressed in brain; integument; liver; and spleen. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dermatitis (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and rhinitis (multiple). Orthologous to human TLR2 (toll like receptor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 10 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu520 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Hu et al., 2023
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tlr2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
colorectal cancer	Alliance	{Colorectal cancer, susceptibility to}	114500
		{Leprosy, susceptibility to}	246300
		{Mycobacterium tuberculosis, susceptibility to}	607948

Associated With tlr2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain
Family	IPR017241	Toll-like receptor
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Homologous_superfamily	IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR003591	Leucine-rich repeat, typical subtype