Gene
ticam1
- ID
- ZDB-GENE-040219-2
- Name
- TIR domain containing adaptor molecule 1
- Symbol
- ticam1 Nomenclature History
- Previous Names
-
- trif (1)
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling and positive regulation of interferon-beta biosynthetic process. Localizes to Golgi apparatus. Human ortholog(s) of this gene implicated in brain disease. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Orthologous to human TICAM1 (toll like receptor adaptor molecule 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 6} | 614850 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | TIR domain-containing adapter molecule 1/2 | Toll/interleukin-1 receptor homology (TIR) domain | Toll/interleukin-1 receptor homology (TIR) domain superfamily | TRIF, N-terminal |
|---|---|---|---|---|---|
|
UniProtKB:Q1LUQ2
|
566 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ticam1-201
(1)
|
Ensembl | 2,318 nt | ||
| mRNA |
ticam1-202
(1)
|
Ensembl | 1,947 nt |
Interactions and Pathways
No data available
Plasmids
No data available