Gene

tlr9

ID

ZDB-GENE-040219-10

Name

toll-like receptor 9

Symbol

tlr9 Nomenclature History

Previous Names

TIR9 (1)
sb:eu392

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have pattern recognition receptor activity. Involved in antibacterial humoral response and toll-like receptor signaling pathway. Localizes to endoplasmic reticulum. Human ortholog(s) of this gene implicated in several diseases, including allergic bronchopulmonary aspergillosis; cystic fibrosis; glomerulonephritis (multiple); hepatitis B; and lung disease (multiple). Is expressed in blood; heart; liver; muscle; and pleuroperitoneal region. Orthologous to human TLR9 (toll like receptor 9).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

15 figures from 8 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu392 (4 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tlr9 Human Ortholog

No data available

Associated With tlr9 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain
Domain	IPR000483	Cysteine-rich flanking region, C-terminal
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Homologous_superfamily	IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR003591	Leucine-rich repeat, typical subtype

Domain Details Per Protein

Protein	Length	Cysteine-rich flanking region, C-terminal	Leucine-rich repeat	Leucine-rich repeat domain superfamily	Leucine-rich repeat, typical subtype	Toll/interleukin-1 receptor homology (TIR) domain	Toll/interleukin-1 receptor homology (TIR) domain superfamily
UniProtKB:B3DJW3 InterPro	1057

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	tlr9-201 (1) Ensembl	Ensembl		3,292 nt	Select Tool ZFIN BLAST
mRNA	tlr9-202 (1) Ensembl	Ensembl		3,881 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations