Gene

mbd4

ID

ZDB-GENE-040213-1

Name

methyl-CpG binding domain protein 4

Symbol

mbd4 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to enable DNA binding activity. Predicted to act upstream of or within DNA repair. Predicted to be active in nucleus. Is expressed in retina and trunk. Human ortholog(s) of this gene implicated in colorectal carcinoma; esophagus squamous cell carcinoma; lung cancer; rheumatoid arthritis; and uveal melanoma. Orthologous to human MBD4 (methyl-CpG binding domain 4, DNA glycosylase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mbd4 Human Ortholog

No data available

Associated With mbd4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR045138	Methyl-CpG binding protein MeCP2/MBD4
Homologous_superfamily	IPR011257	DNA glycosylase

Domain Details Per Protein

Protein	Length	DNA glycosylase	Methyl-CpG binding protein MeCP2/MBD4
UniProtKB:A0A097ZPG7 InterPro	191
UniProtKB:A0A8M6Z2E4 InterPro	294
UniProtKB:A0A8M6Z8A1 InterPro	306

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	mbd4-201 (1) Ensembl	Ensembl		1,505 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations