Gene

figla

ID

ZDB-GENE-031121-1

Name

folliculogenesis specific bHLH transcription factor

Symbol

figla Nomenclature History

Previous Names

fig1a (1)
Figa (1)
FIGalpha (1)
zgc:109752

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have protein dimerization activity. Involved in female gonad development. Human ortholog(s) of this gene implicated in premature ovarian failure. Is expressed in gonad; ovary; and testis. Orthologous to human FIGLA (folliculogenesis specific bHLH transcription factor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:109752 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from Qin et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With figla Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
primary ovarian insufficiency 6	Alliance	Premature ovarian failure 6	612310

Associated With figla Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Family	IPR050283	E-box Binding Transcriptional Regulators
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily