Gene
aph1b
- ID
- ZDB-GENE-031118-31
- Name
- APH1B gamma secretase subunit
- Symbol
- aph1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have endopeptidase activity. Predicted to be involved in Notch receptor processing; Notch signaling pathway; and protein processing. Predicted to localize to endoplasmic reticulum; gamma-secretase complex; and integral component of plasma membrane. Human ortholog(s) of this gene implicated in coronary artery disease. Is expressed in forebrain; hindbrain; midbrain; presumptive neural retina; and trunk. Orthologous to several human genes including APH1B (aph-1 homolog B, gamma-secretase subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Campbell et al., 2006
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Campbell et al., 2006
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR009294 | Gamma-secretase subunit Aph-1 |
Domain Details Per Protein
| Protein | Length | Gamma-secretase subunit Aph-1 |
|---|---|---|
|
UniProtKB:Q8JHE9
|
258 |
Interactions and Pathways
No data available
Plasmids
No data available