Gene
fen1
- ID
- ZDB-GENE-031112-11
- Name
- flap structure-specific endonuclease 1
- Symbol
- fen1 Nomenclature History
- Previous Names
-
- cb879 (1)
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to have metal ion binding activity and nuclease activity. Involved in retina development in camera-type eye. Predicted to localize to nucleus. Is expressed in brain; head; pectoral fin musculature; and proliferative region. Orthologous to human FEN1 (flap structure-specific endonuclease 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb879 (6 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR008918 | Helix-hairpin-helix motif, class 2 |
| Conserved_site | IPR019974 | XPG conserved site |
| Domain | IPR006085 | XPG, N-terminal |
| Domain | IPR006086 | XPG-I domain |
| Family | IPR006084 | XPG/Rad2 endonuclease |
| Family | IPR023426 | Flap endonuclease 1 |
| Homologous_superfamily | IPR029060 | PIN-like domain superfamily |
| Homologous_superfamily | IPR036279 | 5'-3' exonuclease, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | 5'-3' exonuclease, C-terminal domain superfamily | Flap endonuclease 1 | Helix-hairpin-helix motif, class 2 | PIN-like domain superfamily | XPG conserved site | XPG-I domain | XPG, N-terminal | XPG/Rad2 endonuclease |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6TNU4
|
380 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available