Gene

pfkfb4b

ID

ZDB-GENE-031031-4

Name

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4b

Symbol

pfkfb4b Nomenclature History

Previous Names

pfkfb4
pfkfb4l

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Predicted to localize to cytosol. Is expressed in central nervous system; forerunner cell group; intermediate cell mass of mesoderm; neural plate; and ventral mesoderm. Orthologous to human PFKFB4 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:64150 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pfkfb4b Human Ortholog

No data available

Associated With pfkfb4b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR001345	Phosphoglycerate/bisphosphoglycerate mutase, active site
Domain	IPR013079	6-phosphofructo-2-kinase
Family	IPR003094	Fructose-2,6-bisphosphatase
Family	IPR013078	Histidine phosphatase superfamily, clade-1
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR029033	Histidine phosphatase superfamily

Domain Details Per Protein

Protein	Length	6-phosphofructo-2-kinase	Fructose-2,6-bisphosphatase	Histidine phosphatase superfamily	Histidine phosphatase superfamily, clade-1	Phosphoglycerate/bisphosphoglycerate mutase, active site	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:F6NXI0 InterPro	485
UniProtKB:Q7T325 InterPro	469

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pfkfb4b-201 (1) Ensembl	Ensembl	2,684 nt	Select Tool ZFIN BLAST
mRNA	pfkfb4b-202 (1) Ensembl	Ensembl	2,227 nt	Select Tool ZFIN BLAST
ncRNA	pfkfb4b-003 (1) Ensembl	Ensembl	792 nt	Select Tool ZFIN BLAST
ncRNA	pfkfb4b-004 (1) Ensembl	Ensembl	456 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations