Gene

add1

ID

ZDB-GENE-030909-2

Name

adducin 1 (alpha)

Symbol

add1 Nomenclature History

Previous Names

cb787 (1)
zgc:158352

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have actin filament binding activity; spectrin binding activity; and structural molecule activity. Predicted to be involved in several processes, including barbed-end actin filament capping; positive regulation of adherens junction organization; and positive regulation of establishment of endothelial barrier. Predicted to localize to several cellular components, including adherens junction; plasma membrane raft; and postsynaptic density. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; artery disease (multiple); familial combined hyperlipidemia; and gastroschisis. Is expressed in nervous system and pronephric duct. Orthologous to human ADD1 (adducin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

17 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb787 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With add1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
essential hypertension	Alliance	{Hypertension, essential, salt-sensitive}	145500

Associated With add1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001303	Class II aldolase/adducin N-terminal
Family	IPR051017	Aldolase class II Adducin subfamily
Homologous_superfamily	IPR036409	Class II aldolase/adducin N-terminal domain superfamily

Domain Details Per Protein

Protein	Length	Aldolase class II Adducin subfamily	Class II aldolase/adducin N-terminal	Class II aldolase/adducin N-terminal domain superfamily
UniProtKB:A1A5X4 InterPro	741
UniProtKB:A0A8M9PTW3 InterPro	690
UniProtKB:A0A8M9P3B6 InterPro	763
UniProtKB:A0A8M3ATI8 InterPro	698
UniProtKB:A0A8M2B847 InterPro	783
UniProtKB:A0A8M9PQH2 InterPro	732
UniProtKB:A0A8M2B7V9 InterPro	729
UniProtKB:A0A8M9PQG8 InterPro	848