Gene
mmp14b
- ID
- ZDB-GENE-030901-2
- Name
- matrix metallopeptidase 14b (membrane-inserted)
- Symbol
- mmp14b Nomenclature History
- Previous Names
-
- MT-MMPbeta
- zMT-MMP-beta (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have metalloendopeptidase activity and zinc ion binding activity. Involved in several processes, including gastrulation; lamellipodium organization; and regulation of extracellular matrix assembly. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in myocardial infarction. Is expressed in several structures, including axis; connective tissue cell; head; myoseptum; and tail bud. Orthologous to human MMP14 (matrix metallopeptidase 14).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Winchester syndrome | Alliance | Winchester syndrome | 277950 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR021158 | Peptidase M10A, cysteine switch, zinc binding site |
| Conserved_site | IPR018486 | Hemopexin, conserved site |
| Domain | IPR000585 | Hemopexin-like domain |
| Domain | IPR001818 | Peptidase M10, metallopeptidase |
| Domain | IPR002477 | Peptidoglycan binding-like |
| Domain | IPR006026 | Peptidase, metallopeptidase |
| Domain | IPR021805 | Peptidase M10A, matrix metallopeptidase, C-terminal |
| Domain | IPR033739 | Peptidase M10A, catalytic domain |
| Family | IPR021190 | Peptidase M10A |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
| Homologous_superfamily | IPR036365 | PGBD-like superfamily |
| Homologous_superfamily | IPR036375 | Hemopexin-like domain superfamily |
| Repeat | IPR018487 | Hemopexin-like repeats |
Domain Details Per Protein
| Protein | Length | Hemopexin, conserved site | Hemopexin-like domain | Hemopexin-like domain superfamily | Hemopexin-like repeats | Metallopeptidase, catalytic domain superfamily | Peptidase M10A | Peptidase M10A, catalytic domain | Peptidase M10A, cysteine switch, zinc binding site | Peptidase M10A, matrix metallopeptidase, C-terminal | Peptidase M10, metallopeptidase | Peptidase, metallopeptidase | Peptidoglycan binding-like | PGBD-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7T2J1
|
621 | |||||||||||||
|
UniProtKB:B0R0I1
|
621 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mmp14b-201
(1)
|
Ensembl | 4,473 nt |
Interactions and Pathways
No data available
Plasmids
No data available