Gene
ggcx
- ID
- ZDB-GENE-030826-27
- Name
- gamma-glutamyl carboxylase
- Symbol
- ggcx Nomenclature History
- Previous Names
-
- cb751 (1)
- si:ch1073-230p18.3
- zgc:158736
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have gamma-glutamyl carboxylase activity and vitamin binding activity. Predicted to be involved in peptidyl-glutamic acid carboxylation. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in coagulation protein disease and inherited blood coagulation disease. Is expressed in several structures, including axis; digestive system; fin; otic placode; and polster. Orthologous to human GGCX (gamma-glutamyl carboxylase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb751 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| combined deficiency of vitamin K-dependent clotting factors 1 | Alliance | Vitamin K-dependent clotting factors, combined deficiency of, 1 | 277450 |
| Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency | 610842 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR011020 | HTTM-like |
| Domain | IPR053934 | HTTM domain |
| Domain | IPR053935 | Vitamin K-dependent gamma-carboxylase, lumenal domain |
| Family | IPR007782 | Vitamin K-dependent gamma-carboxylase |
| Homologous_superfamily | IPR011051 | RmlC-like cupin domain superfamily |
| Homologous_superfamily | IPR014710 | RmlC-like jelly roll fold |
Domain Details Per Protein
| Protein | Length | HTTM domain | HTTM-like | RmlC-like cupin domain superfamily | RmlC-like jelly roll fold | Vitamin K-dependent gamma-carboxylase | Vitamin K-dependent gamma-carboxylase, lumenal domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1RIV5
|
770 |
Interactions and Pathways
No data available
Plasmids
No data available