Gene

slc26a2

ID

ZDB-GENE-030717-3

Name

solute carrier family 26 member 2

Symbol

slc26a2 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have anion transmembrane transporter activity. Involved in sensory organ development; sensory perception of sound; and swimming behavior. Predicted to localize to integral component of plasma membrane. Human ortholog(s) of this gene implicated in bone disease (multiple). Is expressed in lateral line primordium; midbrain; otic vesicle; pectoral fin bud; and pronephric duct. Orthologous to human SLC26A2 (solute carrier family 26 member 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from Liu et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With slc26a2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
achondrogenesis type IB	Alliance	Achondrogenesis Ib	600972
atelosteogenesis	Alliance	Atelosteogenesis, type II	256050
atelosteogenesis	Alliance	De la Chapelle dysplasia	256050
diastrophic dysplasia	Alliance	Diastrophic dysplasia	222600
diastrophic dysplasia	Alliance	Diastrophic dysplasia, broad bone-platyspondylic variant	222600
multiple epiphyseal dysplasia 4	Alliance	Epiphyseal dysplasia, multiple, 4	226900

Associated With slc26a2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018045	Sulphate anion transporter, conserved site
Domain	IPR002645	STAS domain
Domain	IPR011547	SLC26A/SulP transporter domain
Family	IPR001902	SLC26A/SulP transporter
Homologous_superfamily	IPR036513	STAS domain superfamily

Domain Details Per Protein

Protein	Length	SLC26A/SulP transporter	SLC26A/SulP transporter domain	STAS domain	STAS domain superfamily	Sulphate anion transporter, conserved site
UniProtKB:E7F9I7 InterPro	699

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	slc26a2-201 (1) Ensembl	Ensembl		4,920 nt	Select Tool ZFIN BLAST
mRNA	slc26a2-202 (1) Ensembl	Ensembl		4,690 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations