Gene
ptn
- ID
- ZDB-GENE-030624-1
- Name
- pleiotrophin
- Symbol
- ptn Nomenclature History
- Previous Names
-
- zgc:111787
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Enables growth factor activity. Acts upstream of or within nervous system development. Predicted to be located in extracellular region. Is expressed in central nervous system and pharyngeal arch. Human ortholog(s) of this gene implicated in adrenal carcinoma. Orthologous to human PTN (pleiotrophin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:111787 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Fadlullah et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR020089 | Pleiotrophin/Midkine, N-terminal domain |
| Domain | IPR020090 | Pleiotrophin/Midkine, C-terminal domain |
| Family | IPR000762 | Midkine heparin-binding growth factor |
| Homologous_superfamily | IPR020091 | Pleiotrophin/Midkine disulphide-rich domain superfamily |
| Homologous_superfamily | IPR037122 | Pleiotrophin/Midkine, N-terminal domain superfamily |
| Homologous_superfamily | IPR038130 | Pleiotrophin/Midkine, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | Midkine heparin-binding growth factor | Pleiotrophin/Midkine, C-terminal domain | Pleiotrophin/Midkine, C-terminal domain superfamily | Pleiotrophin/Midkine disulphide-rich domain superfamily | Pleiotrophin/Midkine, N-terminal domain | Pleiotrophin/Midkine, N-terminal domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q502U6
|
158 |
Interactions and Pathways
No data available
Plasmids
No data available