Gene

celsr1a

ID

ZDB-GENE-030616-78

Name

cadherin EGF LAG seven-pass G-type receptor 1a

Symbol

celsr1a Nomenclature History

Previous Names

celsr1
celsr4
fmi1a (1)
zfmi1a (1)
fb15b11
flamingo 1a (1)
frnt
si:bz6l08.1
wu:fb15b11

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Acts upstream of or within several processes, including cell migration involved in gastrulation; neural tube development; and stem cell population maintenance. Predicted to be located in plasma membrane. Is expressed in several structures, including axis; germ ring; muscle; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human CELSR1 (cadherin EGF LAG seven-pass G-type receptor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu873 (1 image)
eu886 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from Li et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With celsr1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Lymphatic malformation 9	619319

Associated With celsr1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000203	GPS motif
Conserved_site	IPR020894	Cadherin conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR001791	Laminin G domain
Domain	IPR001879	GPCR, family 2, extracellular hormone receptor domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR002049	Laminin-type EGF domain
Domain	IPR002126	Cadherin-like
Domain	IPR017981	GPCR, family 2-like, 7TM
Domain	IPR032471	GAIN domain, N-terminal
Family	IPR000832	GPCR, family 2, secretin-like
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR015919	Cadherin-like superfamily
Homologous_superfamily	IPR036445	GPCR family 2, extracellular hormone receptor domain superfamily
Homologous_superfamily	IPR046338	GAIN domain superfamily

Domain Details Per Protein

Protein	Length	Cadherin conserved site	Cadherin-like	Cadherin-like superfamily	Concanavalin A-like lectin/glucanase domain superfamily	EGF-like calcium-binding domain	EGF-like domain	GAIN domain, N-terminal	GAIN domain superfamily	GPCR, family 2, extracellular hormone receptor domain	GPCR family 2, extracellular hormone receptor domain superfamily	GPCR, family 2-like, 7TM	GPCR, family 2, secretin-like	GPS motif	Laminin G domain	Laminin-type EGF domain
UniProtKB:A0A8M3B933 InterPro	3031
UniProtKB:F1R9W4 InterPro	3044
UniProtKB:A0A8M3ARK0 InterPro	3045
UniProtKB:A0A8M3ARU0 InterPro	3018

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	celsr1a-201 (1) Ensembl	Ensembl	11,760 nt	Select Tool ZFIN BLAST
mRNA	celsr1a-202 (1) Ensembl	Ensembl	9,089 nt	Select Tool ZFIN BLAST
mRNA	celsr1a-203 (1) Ensembl	Ensembl	11,679 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations