Gene

cblb

ID

ZDB-GENE-030616-417

Name

Cbl proto-oncogene B, E3 ubiquitin protein ligase

Symbol

cblb Nomenclature History

Previous Names

si:busm1-25n23.1
si:busm1-39l02.2
si:dz25n23.1
si:dz39l02.2

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to enable SH3 domain binding activity; receptor tyrosine kinase binding activity; and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of epidermal growth factor-activated receptor activity and signal transduction. Predicted to act upstream of or within cell surface receptor signaling pathway and regulation of signaling. Predicted to be located in cytoplasm. Predicted to be active in membrane raft and plasma membrane. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; stomach carcinoma; and type 1 diabetes mellitus. Orthologous to human CBLB (Cbl proto-oncogene B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Anelli et al., 2009

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cblb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Autoimmune disease, multisystem, infantile-onset, 3	620430

Associated With cblb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017907	Zinc finger, RING-type, conserved site
Domain	IPR001841	Zinc finger, RING-type
Domain	IPR003153	Adaptor protein Cbl, N-terminal helical
Domain	IPR014741	Adaptor protein Cbl, EF hand-like
Domain	IPR014742	Adaptor protein Cbl, SH2-like domain
Domain	IPR015940	Ubiquitin-associated domain
Domain	IPR018957	Zinc finger, C3HC4 RING-type
Domain	IPR024159	Adaptor protein Cbl, PTB domain
Family	IPR024162	Adaptor protein Cbl
Homologous_superfamily	IPR011992	EF-hand domain pair
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR036537	Adaptor protein Cbl, N-terminal domain superfamily
Homologous_superfamily	IPR036860	SH2 domain superfamily

Domain Details Per Protein

Protein	Length	Adaptor protein Cbl	Adaptor protein Cbl, EF hand-like	Adaptor protein Cbl, N-terminal domain superfamily	Adaptor protein Cbl, N-terminal helical	Adaptor protein Cbl, PTB domain	Adaptor protein Cbl, SH2-like domain	EF-hand domain pair	SH2 domain superfamily	Ubiquitin-associated domain	Zinc finger, C3HC4 RING-type	Zinc finger, RING/FYVE/PHD-type	Zinc finger, RING-type	Zinc finger, RING-type, conserved site
UniProtKB:A0A8M9PFD0 InterPro	939
UniProtKB:A0A8M9PAD4 InterPro	184
UniProtKB:F1Q742 InterPro	939

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cblb-201 (1) Ensembl	Ensembl	6,532 nt	Select Tool ZFIN BLAST
mRNA	cblb-202 (1) Ensembl	Ensembl	3,845 nt	Select Tool ZFIN BLAST
mRNA	ottdart00000001912 (1)	Havana	2,156 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ottdart00000001985 (1)	Havana	2,047 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations