Gene
ivd
- ID
- ZDB-GENE-030616-262
- Name
- isovaleryl-CoA dehydrogenase
- Symbol
- ivd Nomenclature History
- Previous Names
-
- sb:cb425
- si:dz181p14.1
- wu:fb34d07
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have isovaleryl-CoA dehydrogenase activity. Predicted to be involved in oxidation-reduction process. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and isovaleric acidemia. Is expressed in alar plate midbrain region; digestive system; immature eye; musculature system; and optic tectum. Orthologous to human IVD (isovaleryl-CoA dehydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb425 (16 images)
- IMAGE:7136352 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| isovaleric acidemia | Alliance | Isovaleric acidemia | 243500 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR006089 | Acyl-CoA dehydrogenase, conserved site |
| Domain | IPR006091 | Acyl-CoA oxidase/dehydrogenase, middle domain |
| Domain | IPR009075 | Acyl-CoA dehydrogenase/oxidase, C-terminal |
| Domain | IPR013786 | Acyl-CoA dehydrogenase/oxidase, N-terminal |
| Family | IPR034183 | Isovaleryl-CoA dehydrogenase |
| Homologous_superfamily | IPR009100 | Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily |
| Homologous_superfamily | IPR036250 | Acyl-CoA dehydrogenase-like, C-terminal |
| Homologous_superfamily | IPR037069 | Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily |
| Homologous_superfamily | IPR046373 | Acyl-CoA oxidase/dehydrogenase, middle domain superfamily |
Domain Details Per Protein
| Protein | Length | Acyl-CoA dehydrogenase, conserved site | Acyl-CoA dehydrogenase-like, C-terminal | Acyl-CoA dehydrogenase/oxidase, C-terminal | Acyl-CoA dehydrogenase/oxidase, N-terminal | Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily | Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily | Acyl-CoA oxidase/dehydrogenase, middle domain | Acyl-CoA oxidase/dehydrogenase, middle domain superfamily | Isovaleryl-CoA dehydrogenase |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZTH9
|
418 |
Interactions and Pathways
No data available
Plasmids
No data available