Gene

map4k2

ID

ZDB-GENE-030616-163

Name

mitogen-activated protein kinase kinase kinase kinase 2

Symbol

map4k2 Nomenclature History

Previous Names

map4k2l
si:dz150l22.2
si:dz263j20.1
zgc:136670

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to enable MAP kinase kinase kinase kinase activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytoplasm. Orthologous to human MAP4K2 (mitogen-activated protein kinase kinase kinase kinase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Nguyen et al., 2011

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With map4k2 Human Ortholog

No data available

Associated With map4k2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR001180	Citron homology (CNH) domain
Family	IPR021160	Mitogen-activated protein (MAP) kinase kinase kinase kinase
Family	IPR050629	STE20/SPS1-related Proline-Alanine-rich Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	Citron homology (CNH) domain	Mitogen-activated protein (MAP) kinase kinase kinase kinase	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	STE20/SPS1-related Proline-Alanine-rich Kinase
UniProtKB:Q1RLZ2 InterPro	865

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	map4k2-201 (1) Ensembl	Ensembl	3,149 nt	Select Tool ZFIN BLAST
mRNA	map4k2-202 (1) Ensembl	Ensembl	704 nt	Select Tool ZFIN BLAST
mRNA	ottdart00000004121 (1)	Havana	2,945 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ottdart00000004126 (1)	Havana	3,107 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ottdart00000004127 (1)	Havana	2,408 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ottdart00000004128 (1)	Havana	1,517 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations