Gene
adh8b
- ID
- ZDB-GENE-030529-2
- Name
- alcohol dehydrogenase 8b
- Symbol
- adh8b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Exhibits alcohol dehydrogenase (NAD+) activity and formaldehyde dehydrogenase activity. Involved in formaldehyde metabolic process and octanol metabolic process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in alcohol use disorder; late onset Parkinson's disease; and pancreatic cancer. Is expressed in female organism; intestine; liver; ovary; and yolk syncytial layer. Orthologous to several human genes including ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide); ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide); and ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7148076 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR002328 | Alcohol dehydrogenase, zinc-type, conserved site |
| Domain | IPR013149 | Alcohol dehydrogenase-like, C-terminal |
| Domain | IPR013154 | Alcohol dehydrogenase-like, N-terminal |
| Domain | IPR020843 | Polyketide synthase, enoylreductase domain |
| Homologous_superfamily | IPR011032 | GroES-like superfamily |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Alcohol dehydrogenase-like, C-terminal | Alcohol dehydrogenase-like, N-terminal | Alcohol dehydrogenase, zinc-type, conserved site | GroES-like superfamily | NAD(P)-binding domain superfamily | Polyketide synthase, enoylreductase domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7T2J4
|
376 |
Interactions and Pathways
No data available
Plasmids
No data available