Gene

dio1

ID

ZDB-GENE-030328-41

Name

iodothyronine deiodinase 1

Symbol

dio1 Nomenclature History

Previous Names

Deio1 (1)
cb685 (1)
zgc:92323

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have thyroxine 5'-deiodinase activity. Involved in regulation of neural retina development. Predicted to localize to integral component of membrane. Is expressed in several structures, including eye; female organism; heart; liver; and male organism. Orthologous to human DIO1 (iodothyronine deiodinase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 10 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb685 (4 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dio1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Thyroid hormone metabolism, abnormal, 2	619855

Associated With dio1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008261	Iodothyronine deiodinase, active site
Family	IPR000643	Iodothyronine deiodinase
Homologous_superfamily	IPR036249	Thioredoxin-like superfamily