Gene
dlst
- ID
- ZDB-GENE-030326-1
- Name
- dihydrolipoamide S-succinyltransferase
- Symbol
- dlst Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable dihydrolipoyllysine-residue succinyltransferase activity. Acts upstream of or within several processes, including ATP biosynthetic process; heart contraction; and mitochondrion organization. Predicted to be located in mitochondrial matrix. Predicted to be part of oxoglutarate dehydrogenase complex. Predicted to be active in mitochondrion. Is expressed in several structures, including immature eye; musculature system; nervous system; neural plate; and segmental plate. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb60 (31 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Pheochromocytoma/paraganglioma syndrome 7 | 618475 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR003016 | 2-oxo acid dehydrogenase, lipoyl-binding site |
| Domain | IPR000089 | Biotin/lipoyl attachment |
| Domain | IPR001078 | 2-oxoacid dehydrogenase acyltransferase, catalytic domain |
| Family | IPR006255 | Dihydrolipoamide succinyltransferase |
| Family | IPR050537 | 2-oxoacid dehydrogenase |
| Homologous_superfamily | IPR011053 | Single hybrid motif |
| Homologous_superfamily | IPR023213 | Chloramphenicol acetyltransferase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | 2-oxoacid dehydrogenase | 2-oxoacid dehydrogenase acyltransferase, catalytic domain | 2-oxo acid dehydrogenase, lipoyl-binding site | Biotin/lipoyl attachment | Chloramphenicol acetyltransferase-like domain superfamily | Dihydrolipoamide succinyltransferase | Single hybrid motif |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZVL3
|
458 |
Interactions and Pathways
No data available
Plasmids
No data available