Gene
chrm2a
- ID
- ZDB-GENE-030314-1
- Name
- cholinergic receptor, muscarinic 2a
- Symbol
- chrm2a Nomenclature History
- Previous Names
-
- chrm2
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to have G protein-coupled acetylcholine receptor activity and G protein-coupled serotonin receptor activity. Involved in negative regulation of heart rate. Predicted to localize to dendrite; integral component of plasma membrane; and synapse. Human ortholog(s) of this gene implicated in several diseases, including Chagas disease; asthma; bipolar disorder; heroin dependence; and major depressive disorder. Is expressed in several structures, including cardiovascular system; central nervous system; digestive system; head; and neural tube. Orthologous to human CHRM2 (cholinergic receptor muscarinic 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu64 (6 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Muscarinic acetylcholine receptor family | Muscarinic acetylcholine receptor M2 |
|---|---|---|---|---|---|
|
UniProtKB:B3DKN8
|
495 | ||||
|
UniProtKB:Q801M4
|
495 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
chrm2a-201
(1)
|
Ensembl | 1,754 nt | ||
| mRNA |
chrm2a-202
(1)
|
Ensembl | 1,605 nt |
Interactions and Pathways
No data available
Plasmids
No data available