Gene

tiam2a

ID

ZDB-GENE-030219-98

Name

TIAM Rac1 associated GEF 2a

Symbol

tiam2a Nomenclature History

Previous Names

id:ibd5033

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in activation of GTPase activity; positive regulation of axonogenesis; and small GTPase mediated signal transduction. Predicted to act upstream of or within intracellular signal transduction. Predicted to be active in membrane and synapse. Is expressed in somite and tail bud. Orthologous to human TIAM2 (TIAM Rac1 associated GEF 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from Kudoh et al., 2001

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tiam2a Human Ortholog

No data available

Associated With tiam2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Domain	IPR000219	Dbl homology (DH) domain
Domain	IPR001478	PDZ domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR003116	Raf-like Ras-binding
Domain	IPR040655	TIAM1, CC-Ex domain
Family	IPR043537	Tiam1/Tiam2/Protein still life
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR036034	PDZ superfamily

Domain Details Per Protein

Protein	Length	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	Guanine-nucleotide dissociation stimulator, CDC24, conserved site	PDZ domain	PDZ superfamily	PH-like domain superfamily	Pleckstrin homology domain	Raf-like Ras-binding	TIAM1, CC-Ex domain	Tiam1/Tiam2/Protein still life
UniProtKB:A0A286Y9S9 InterPro	1671
UniProtKB:A0A8M3AJ94 InterPro	1686
UniProtKB:A0A8M3AK43 InterPro	728
UniProtKB:A0A8M9PLL7 InterPro	673

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tiam2a-201 (1) Ensembl	Ensembl	6,529 nt	Select Tool ZFIN BLAST
mRNA	tiam2a-202 (1) Ensembl	Ensembl	558 nt	Select Tool ZFIN BLAST
mRNA	tiam2a-203 (1) Ensembl	Ensembl	5,106 nt	Select Tool ZFIN BLAST
mRNA	tiam2a-204 (1) Ensembl	Ensembl	5,049 nt	Select Tool ZFIN BLAST
mRNA	tiam2a-205 (1) Ensembl	Ensembl	5,583 nt	Select Tool ZFIN BLAST
mRNA	tiam2a-206 (1) Ensembl	Ensembl	4,843 nt	Select Tool ZFIN BLAST
mRNA	tiam2a-207 (1) Ensembl	Ensembl	4,716 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations