Gene
hells
- ID
- ZDB-GENE-030131-9923
- Name
- helicase, lymphoid specific
- Symbol
- hells Nomenclature History
- Previous Names
-
- cb65 (1)
- im:6911667
- sb:cb65
- sb:cb749
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to have DNA binding activity and DNA-dependent ATPase activity. Involved in regulation of DNA methylation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 4. Is expressed in several structures, including alar plate midbrain region; central nervous system; immature eye; margin; and pectoral fin musculature. Orthologous to human HELLS (helicase, lymphoid specific).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb65 (7 images)
- cb749 (18 images)
- IMAGE:6911667 (3 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Dunican et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency-centromeric instability-facial anomalies syndrome 4 | Alliance | Immunodeficiency-centromeric instability-facial anomalies syndrome 4 | 616911 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000330 | SNF2, N-terminal |
| Domain | IPR001650 | Helicase, C-terminal domain-like |
| Domain | IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| Domain | IPR044753 | HELLS, N-terminal |
| Domain | IPR049730 | SNF2/RAD5-like, C-terminal helicase domain |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR038718 | SNF2-like, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | Helicase, C-terminal domain-like | Helicase superfamily 1/2, ATP-binding domain | HELLS, N-terminal | P-loop containing nucleoside triphosphate hydrolase | SNF2-like, N-terminal domain superfamily | SNF2, N-terminal | SNF2/RAD5-like, C-terminal helicase domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q3BDS6
|
853 |
Interactions and Pathways
No data available
Plasmids
No data available