Gene

kdm7aa

ID

ZDB-GENE-030131-9829

Name

lysine (K)-specific demethylase 7Aa

Symbol

kdm7aa Nomenclature History

Previous Names

kdm7a (1)
cb414 (1)
jhdm1da
sb:cb414
si:dkey-105o6.2
zgc:123306

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Exhibits histone demethylase activity (H3-K27 specific) and histone demethylase activity (H3-K9 specific). Involved in histone H3-K27 demethylation; histone H3-K9 demethylation; and midbrain development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in melanoma. Is expressed in several structures, including anterior axial hypoblast; immature eye; margin; mesoderm; and nervous system. Orthologous to human KDM7A (lysine demethylase 7A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb414 (18 images)
IMAGE:7139974 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kdm7aa Human Ortholog

No data available

Associated With kdm7aa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019786	Zinc finger, PHD-type, conserved site
Domain	IPR001965	Zinc finger, PHD-type
Domain	IPR003347	JmjC domain
Domain	IPR019787	Zinc finger, PHD-finger
Domain	IPR041070	Jumonji, helical domain
Family	IPR050690	JHDM1 Histone Demethylase
Homologous_superfamily	IPR011011	Zinc finger, FYVE/PHD-type

Domain Details Per Protein

Protein	Length	JHDM1 Histone Demethylase	JmjC domain	Jumonji, helical domain	Zinc finger, FYVE/PHD-type	Zinc finger, PHD-finger	Zinc finger, PHD-type	Zinc finger, PHD-type, conserved site
UniProtKB:A0A2R8RKB3 InterPro	837
UniProtKB:Q5RHD1 InterPro	875

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	kdm7aa-201 (1) Ensembl	Ensembl	1,848 nt	Select Tool ZFIN BLAST
mRNA	kdm7aa-202 (1) Ensembl	Ensembl	841 nt	Select Tool ZFIN BLAST
mRNA	kdm7aa-203 (1) Ensembl	Ensembl	2,628 nt	Select Tool ZFIN BLAST
mRNA	kdm7aa-204 (1) Ensembl	Ensembl	3,094 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations